HCID 22335453, compound → HCID 131725107, compound

HRID 586811Notes

Reaction equation

HRID 586811 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]([F:14])([F:13])[C:10]([OH:12])=[O:11].[CH3:15][C:16]1[CH:25]=[C:24]([CH2:26][O:27][C:28]2[CH:33]=[CH:32][C:31]([C:34]3([N:43]4[CH2:48][CH2:47][N:46](C(OC(C)(C)C)=O)[CH2:45][CH2:44]4)[C:39](=[O:40])[NH:38][C:37](=[O:41])[NH:36][C:35]3=[O:42])=[CH:30][CH:29]=2)[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=1>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]([F:14])([F:13])[C:10]([OH:12])=[O:11].[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:15][C:16]1[CH:25]=[C:24]([CH2:26][O:27][C:28]2[CH:29]=[CH:30][C:31]([C:34]3([N:43]4[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]4)[C:39](=[O:40])[NH:38][C:37](=[O:41])[NH:36][C:35]3=[O:42])=[CH:32][CH:33]=2)[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=1

Participants

3

Reactant 1

HCID 22335453HCID 22335453, compound

Product 1

HCID 131725107HCID 131725107, compoundYield 199.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from example 13 (50 mg, 0.0635 mmol) was treated with trifluoacetic acid (2.0 mL) in dichloromethane (2.0 mL) at rt for 1 h. The mixture was concentrated in vacuo to provide the title barbituric acid (50.8 mg, 100%). MS found: (M+H)+=460.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-2475f9afd6654763960f4e4fc7426ba4
Source dataset
uspto-grants-2005_08
Patent number
US06936620B2

Reaction notes

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