反应详情

In THF (20 ml) was dissolved (2,4-dimethyl-1,3-thiazol-5-yl)methanol (1.0 g). To the solution was added active manganese dioxide (6.0 g), and the mixture was stirred at room temperature for 3 hours. To the mixture was added active manganese dioxide (3.0 g), and the mixture was stirred at room temperature for 1 hour. The mixture was filtered with Celite and washed with methanol. The solvent was removed under reduced pressure, and the resulting residue was purified with silica gel column chromatography (hexane/ethyl acetate/methanol=10/10/1) to give 2,4-dimethyl-1,3-thiazole-5-carbaldehyde (0.32 g).

1. stirringthe mixture was stirred at room temperature for 1 hour
2. filtrationThe mixture was filtered with Celite
3. washwashed with methanol
4. customThe solvent was removed under reduced pressure
5. customthe resulting residue was purified with silica gel column chromatography (hexane/ethyl acetate/methanol=10/10/1)