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HRID587081

反应详情

EQUATION

反应方程式

HRID 587081 的结构方程式

REACTANTS

反应物

2
结构：CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCN3CCC)cc1
HCID3009408

7-[4-(2-butoxyethoxy)phenyl]-1-propyl-N-[4-[[N-methyl-N-(tetrahydropyran-4-yl)amino]methyl]phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxamide

C39H51N3O4

结构：CCOC(C)=O.Cl
HCID21866389

未命名化合物

PRODUCTS

生成物

1
结构：CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CCN3CCC)cc1.Cl.Cl
HCID22329066

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a solution of 7-[4-(2-butoxyethoxy)phenyl]-1-propyl-N-[4-[[N-methyl-N-(tetrahydropyran-4-yl)amino]methyl]phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxamide (16.4 g) in ethyl acetate (1500 ml) was added 4N hydrochloric acid-ethyl acetate (25 ml) at room temperature, and the mixture was stirred for 1 hour. The precipitated crystals were collected by filtration, which was purified by recrystallization (2-propanol) to give 7-[4-(2-butoxyethoxy)phenyl]-1-propyl-N-[4-[[N-methyl-N-(tetrahydropyran-4-yl)amino]methyl]phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxamide dihydrochloride (Compound 109) (8.61 g) as pale yellow crystals.

WORKUP

后处理

  1. filtrationThe precipitated crystals were collected by filtration, which
  2. customwas purified by recrystallization (2-propanol)