2-(Methoxymethyl)piperidine hydrochloride → rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	2-(Methoxymethyl)piperidine hydrochloride	HCID 45926159	—
Reactant	3-[(4-(4,4-Difluoropiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide	HCID 60197102	—
Reactant	3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide	HCID 86679822	—
Product	rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide	HCID 60197106	—

Reaction Steps

B4 was prepared following the procedure reported for B2 using A1 and rac-2-methoxymethylpiperidine hydrochloride. The title compound was purified by thick-layer chromatography (silica gel, chloroform/MeOH 19:1) and obtained as a white crystalline solid; yield: 235 mg (67%). MS (ES) C17H24N6O3S requires: 392. found: 393 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09226929B2
Source dataset	uspto-grants-2016_01
ORD ID	ord-db7379088f3d4dcca8d5b74f80ebf560
Source note	uspto-grants-2016_01