1-Methylpiperazine → 3-[(4-(4-Methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

HRID 587147Notes

Reaction equation

HRID 587147 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:15]=[C:16]([CH2:20][S:21]([NH2:24])(=[O:23])=[O:22])[CH:17]=[CH:18][CH:19]=3)[N:8]=2)[CH2:6][CH2:5]C[CH2:3][CH2:2]1.Cl[C:26]1N=CN=C(NC2C=C(CS(N)(=O)=O)C=CC=2)[N:27]=1.CN1CCNCC1>>[CH3:26][N:27]1[CH2:5][CH2:6][N:1]([C:7]2[N:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:15]=[C:16]([CH2:20][S:21]([NH2:24])(=[O:23])=[O:22])[CH:17]=[CH:18][CH:19]=3)[N:8]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 601971013-[(4-(Piperidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethane sulfonamideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 601972003-[(4-(4-Methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

Procedure

B12 was prepared following the procedure reported for B1 using A1 and N-methylpiperazine. MS (ES) C15H21N7O3S requires: 363. found: 364 (M+H)+.

Workup

  1. customB12 was prepared

Sources & evidence

ORD record
ord-092ca2f814b6441d89f41aaec58e229b
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

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