6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride → 3-[(4-(5H-Pyrrolo[3,4-b]pyridin-6(7H)-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

HRID 587180Notes

Reaction equation

HRID 587180 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=2)[N:3]=1.Cl.[N:21]1[CH:26]=[CH:25][CH:24]=[C:23]2[CH2:27][NH:28][CH2:29][C:22]=12>>[N:21]1[CH:26]=[CH:25][CH:24]=[C:23]2[CH2:27][N:28]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=4)[N:3]=3)[CH2:29][C:22]=12

Participants

3

Reactant 2

HCID 189536436,7-Dihydro-5H-pyrrolo[3,4-b]pyridine hydrochlorideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 601978083-[(4-(5H-Pyrrolo[3,4-b]pyridin-6(7H)-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

Procedure

B48 was prepared following the general procedure reported for B10 using A1 and 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride; yield: 92.2 mg (24%), dark amorphous solid. MS (ES) C17H17N7O2S requires: 383. found: 384 (M+H)+.

Workup

  1. customB48 was prepared

Sources & evidence

ORD record
ord-db2f1374c77744c380786e7863fc6c4b
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

Loading…