6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride → 3-[(4-(5H-Pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

HRID 587182Notes

Reaction equation

HRID 587182 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=2)[N:3]=1.Cl.[N:21]1[C:26]2[CH2:27][NH:28][CH2:29][C:25]=2[CH:24]=[N:23][CH:22]=1>>[N:21]1[C:26]2[CH2:27][N:28]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=4)[N:3]=3)[CH2:29][C:25]=2[CH:24]=[N:23][CH:22]=1

Participants

3

Reactant 2

HCID 547588476,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochlorideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 601978103-[(4-(5H-Pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

Procedure

B50 was prepared following the general procedure reported for B10 using A1 and 6,7-dihydro-5H-pyrrolo[3,4-d]pyrim idine hydrochloride; yield: 205.4 mg (53%), colorless amorphous solid. MS (ES) C16H16N8O2S requires: 384. found: 385 (M+H)+.

Workup

  1. customB50 was prepared

Sources & evidence

ORD record
ord-4219b9baea0b4cfdb035e4c0fe1893fd
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

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