反应详情

To a solution of (4-chloro-phenyl)-propynoic acid ethyl ester (92.65 g, 444.1 mmol) in dichloromethane (425 mL) was added trifluoroacetic acid (3.4, 44.4 mmol). The reaction mixture was cooled with a water bath and a solution of N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine (164.7 g, 666.1 mmol) in dichloromethane (325 mL) was added dropwise over a period of 1.5 h. It was stirred for 22 h at ambient temperature. Further N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine (27.5 g, 111.0 mmol) in dichloromethane (50 mL) was added and stirring was continued for 2 h at ambient temperature. The solvent was distilled off and the residue was taken up in dioxane (950 mL). After addition of water (475 mL) and sodium hydroxide (32%, 114.3 mL, 1.23 mol), it was stirred for 67 h at ambient temperature. After concentration the residue was diluted with water (400 mL) and extracted with tert-butylmethylether (400 mL). The organic layers were washed with water (400 mL). The aqueous layers were combined, cooled to 5° C. and set to pH=1.5 with aqueous HCl (25%, 172). After stirring for 1 h at 5° C., the solid was filtered off and was washed with water (1400 mL) and ethanol (400 mL). Drying (50° C., 25 mbar) afforded the title compound (109.85 g, 79%) as an off-white solid. MS m/e: 312.2/314.1 [M−H]−.

1. temperatureThe reaction mixture was cooled with a water bath
2. stirringstirring
3. waitwas continued for 2 h at ambient temperature
4. distillationThe solvent was distilled off
5. stirringwas stirred for 67 h at ambient temperature
6. concentrationAfter concentration the residue
7. additionwas diluted with water (400 mL)
8. extractionextracted with tert-butylmethylether (400 mL)
9. washThe organic layers were washed with water (400 mL)
10. temperaturecooled to 5° C.
11. stirringAfter stirring for 1 h at 5° C.
12. filtrationthe solid was filtered off
13. washwas washed with water (1400 mL) and ethanol (400 mL)
14. customDrying (50° C., 25 mbar)