Lithium hydroxide, monohydrate → HCID 58171834, compound

HRID 587396Notes

Reaction equation

HRID 587396 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]=[N:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=2)[CH2:8][CH2:7]1)=[O:5])C.O[Li].O>>[CH3:19][O:18][C:15]1[N:14]=[N:13][C:12]([N:9]2[CH2:8][CH2:7][CH:6]([C:4]([OH:5])=[O:3])[CH2:11][CH2:10]2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 58303086HCID 58303086, compound

Product 1

HCID 58171834HCID 58171834, compound

Procedure

In analogy to the procedure described for the synthesis of 5′-Fluoro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid the title compound was prepared from 1-(6-Methoxy-pyridazin-3-yl)-piperidine-4-carboxylic acid ethyl ester through saponification with LiOH.H2O. The title compound was isolated as orange solid. MS m/e: 236.2 [M−H].

Sources & evidence

ORD record
ord-34d0307ea72342dfa643c62a638b85cf
Source dataset
uspto-grants-2016_01
Patent number
US09226916B2

Reaction notes

Loading…