Lithium hydroxide, monohydrate → HCID 58302997, compound

HRID 587397Notes

Reaction equation

HRID 587397 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[N:14][C:15]([C:18]#[N:19])=[CH:16][CH:17]=2)[CH2:8][CH2:7]1)=[O:5])C.O[Li].O>>[C:18]([C:15]1[N:14]=[CH:13][C:12]([N:9]2[CH2:8][CH2:7][CH:6]([C:4]([OH:5])=[O:3])[CH2:11][CH2:10]2)=[CH:17][CH:16]=1)#[N:19]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 58302996HCID 58302996, compound

Product 1

HCID 58302997HCID 58302997, compound

Procedure

In analogy to the procedure described for the synthesis of 5′-Fluoro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid the title compound was prepared from 6′-Cyano-3,4,5,6-tetrahydro-2H-[1,3′]bipyridinyl-4-carboxylic acid ethyl ester through saponification with LiOH.H2O. The title compound was isolated as yellow solid. MS m/e: 230 [M−H].

Sources & evidence

ORD record
ord-84211627f09145159d07e3b9b20b0fca
Source dataset
uspto-grants-2016_01
Patent number
US09226916B2

Reaction notes

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