反应详情

温度

60 °C

The mixture of N-methylbenzylamine (6.085 mL), TEA (13.19 mL) and 3-chloro-2-nitropyridine (5 g) was stirred at 60° C. under N2 overnight. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with 0%-30% EtOAc in hexane) to give N-benzyl-N-methyl-2-nitropyridin-3-amine (2.6 g) as dark yellow oil.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customThe residue was purified by column chromatography (silica gel, eluted with 0%-30% EtOAc in hexane)