HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → 8-Cyano-7-(4-phenylpiperidinyl)[1,2,4]triazolo[4,3-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | [3-Cyano-4-(4-phenylpiperidinyl)pyridin-2-yl]-hydrazine | HCID 66787505 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 8-Cyano-7-(4-phenylpiperidinyl)[1,2,4]triazolo[4,3-a]pyridine | HCID 66788831 | 90.1% |
Reaction Steps
D7 (1 g, 3.409 mmol) and triethylorthoformate (7.577 g, 51.13 mmol) in xylene (25 ml) were heated in a sealed tube at 180° C. for 1 h. After cooling, the resulting mixture was concentrated in vacuo. The residue thus obtained was triturated with Et2O to yield compound D8 (0.932 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09226930B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-cb0830f865244359af3a3873767ab099 |
| Source note | uspto-grants-2016_01 |