Hydrochloric Acid → Methyl 4-amino-5-chloro-2-methoxybenzoate

HRID 5877Notes

Reaction equation

HRID 5877 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl.[CH3:15]O>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([O:7][CH3:15])=[O:6]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 816264-Amino-5-chloro-2-methoxybenzoic acid

Product 1

HCID 700493Methyl 4-amino-5-chloro-2-methoxybenzoate

Procedure

To a solution of 50g of 2-methoxy-4-amino-5-chlorobenzoic acid in 500 ml of methanol is added HCl gas until all the material dissolves. Stirring is continued overnight, the solvent removed, ether added, filtered, dried over magnesium sulfate and evaporated to dryness to obtain methyl 2-methoxy-4-amino-5-chlorobenzoate which is used directly in the next step.

Workup

  1. dissolutiondissolves
  2. customthe solvent removed
  3. additionether added
  4. filtrationfiltered
  5. dry with materialdried over magnesium sulfate
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-1eb26c95049e45f5a0d34f4298931c2b
Source dataset
uspto-grants-1993_09
Patent number
US05246942

Reaction notes

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