反应详情

温度

80 °C

To the toluene (30 ml) solution in which 4-amino-N-[2,6-dichloro-4-(1,1,1,2,3,3,3-heptafluoro propan-2-yl)phenyl]benzamide (2.80 g) is dissolved, N-chlorosuccinimide (0.87 g) was added. The reaction solution was stirred for 6 hours at 80° C. under heating. The solution was cooled to room temperature, diluted with water and extracted twice with ethyl acetate. The organic phases were combined, and then dried over magnesium sulfate. The drying agent was removed by filtration, and the solvent was distilled off under reduced pressure to obtain a crude product, which was then separated and purified by column chromatography to give 4-amino-3-chloro-N-[2,6-dichloro-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl] benzamide (2.03 g, yield 67.3%).

1. temperatureunder heating
2. temperatureThe solution was cooled to room temperature
3. extractionextracted twice with ethyl acetate
4. dry with materialdried over magnesium sulfate
5. customThe drying agent was removed by filtration
6. distillationthe solvent was distilled off under reduced pressure
7. customto obtain a crude product, which
8. customwas then separated
9. custompurified by column chromatography