Water → HCID 68479867, compound

Temperature

22 °C

To a solution of 1.01 g (6.09 mmol) of 5-formyl-2-hydroxybenzoic acid in 25 mL of acetone was added 4.25 g (30.5 mmol) of potassium carbonate and 1.15 mL (18.3 mmol) of iodomethane. The mixture was heated to reflux for about 16 h, cooled to 22° C. and filtered. The collected solid was washed with acetone. The filtrates were combined, evaporated and the residue purified by flash chromatography on silica gel eluting with a mixture of hexane and ethyl acetate to give methyl 5-formyl-2-methoxybenzoate as an off-white solid. To a solution of 0.609 g (3.66 mmol) of 5-formyl-2-methoxybenzoate in 10 mL of acetic acid at 22° C. was added 2.2 mL (22 mmol) of n-butylamine followed by 0.337 mL (5.50 mmol) of nitromethane. The mixture was heated to reflux for 3 h, cooled to 22° C. and poured into 250 mL of water. A yellow precipitate resulted which dissolved when the mixture was extracted with 200 mL of ethyl acetate. The organic layer was washed with saturated NaHCO3 (2×100 mL), dried (Na2SO4) and evaporated. The residue was purified by flash chromatography on silica gel eluting with a mixture of hexane and ethyl acetate to give methyl 2-methoxy-5-(2-nitrovinyl)benzoate.

1. temperatureThe mixture was heated
2. temperatureto reflux for 3 h
3. customA yellow precipitate resulted which
4. dissolutiondissolved when the mixture
5. extractionwas extracted with 200 mL of ethyl acetate
6. washThe organic layer was washed with saturated NaHCO3 (2×100 mL)
7. dry with materialdried (Na2SO4)
8. customevaporated
9. customThe residue was purified by flash chromatography on silica gel eluting with a mixture of hexane and ethyl acetate

ORD record

ord-1187963f9e3944f8a36792318c1b0d0b

Source dataset

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09227918B2