Methyl 3-(6-bromo-3-cyano-2-methylhexan-3-yl)benzoate → Methyl 3-(2-((4-cyano-4-(3-(methoxycarbonyl)phenyl)-5-methylhexyl)(methyl)amino)ethyl)benzoate
Reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]([C:11]1[CH:12]=[C:13]([CH:18]=[CH:19][CH:20]=1)[C:14]([O:16][CH3:17])=[O:15])([C:9]#[N:10])[CH:6]([CH3:8])[CH3:7].[CH3:21][NH:22][CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH:32]=[CH:33][CH:34]=1)[C:28]([O:30][CH3:31])=[O:29]>>[C:9]([C:5]([C:11]1[CH:20]=[CH:19][CH:18]=[C:13]([C:14]([O:16][CH3:17])=[O:15])[CH:12]=1)([CH:6]([CH3:8])[CH3:7])[CH2:4][CH2:3][CH2:2][N:22]([CH3:21])[CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH:32]=[CH:33][CH:34]=1)[C:28]([O:30][CH3:31])=[O:29])#[N:10]Participants
3
Procedure
Reaction of 1r with 2d produced 3ap. MS found M+H=451. The oxalate salt of 3ap was recrystallized from methanol/ether; mp 129-136° C.
Workup
- customproduced 3ap
- customThe oxalate salt of 3ap was recrystallized from methanol/ether
Sources & evidence
- ORD record
- ord-f8b217307e754e4a800e57f913f955a4
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09227918B2
Reaction notes
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