Triethyl phosphite → methyl 2-(diethoxyphosphoryl)-propionate

HRID 587975Notes

Reaction equation

Br[CH:2]([CH3:7])[C:3]([O:5][CH3:6])=[O:4].[CH2:8]([O:10][P:11]([O:15]CC)[O:12][CH2:13][CH3:14])[CH3:9]>>[CH3:6][O:5][C:3](=[O:4])[CH:2]([P:11]([O:12][CH2:13][CH3:14])([O:10][CH2:8][CH3:9])=[O:15])[CH3:7]

Participants

Reactant 2

HCID 31215Triethyl phosphite

HCID 95576Methyl 2-bromopropionate

Product 1

HCID 11401826methyl 2-(diethoxyphosphoryl)-propionate

Conditions

Temperature: 110 °C

Procedure

Methyl 2-bromopropionate (100 g, 0.60 mol) and triethylphosphite (109 g, 0.66 mol) were mixed, and the mixture was stirred at 110° C. for 2 days. The reaction mixture was dried under reduced pressure to give the title compound.

Workup

customThe reaction mixture was dried under reduced pressure

Sources & evidence

ORD record: ord-365f9107df57404081fd4befcb9e8d3f
Source dataset: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09227949B2

Reaction notes

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