Hydrochloric Acid → HCID 66589488, compound

HRID 588022Notes

Reaction equation

HRID 588022 reaction equation
C(OC([NH:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[C:17]([NH:19][C:20]([NH:22][CH2:23][C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[C:29](=[O:33])[N:28]([CH:34]2[CH2:39][CH2:38][C:37](=[O:40])[NH:36][C:35]2=[O:41])[CH2:27]3)=[O:21])[CH:16]=[CH:15][C:14]=1[CH3:42])=[O:11])=O)(C)(C)C.[ClH:43]>C(Cl)Cl.CCOCC>[ClH:43].[NH2:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[C:17]([NH:19][C:20]([NH:22][CH2:23][C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[C:29](=[O:33])[N:28]([CH:34]2[CH2:39][CH2:38][C:37](=[O:40])[NH:36][C:35]2=[O:41])[CH2:27]3)=[O:21])[CH:16]=[CH:15][C:14]=1[CH3:42])=[O:11]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66589507HCID 66589507, compound

Product 1

HCID 66589488HCID 66589488, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a mixture of 5-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)ureido)-2-methylphenyl 2-(tert-butoxycarbonylamino)acetate (0.58 g, 1.0 mmol) in DCM (50 mL) is added 2M HCl in ether (1 mL), and the mixture is stirred for 24 hrs. The solid precipitate is filtered, rinsed with DCM (10 mL), and dried under vacuum to provide the product.

Workup

  1. filtrationThe solid precipitate is filtered
  2. washrinsed with DCM (10 mL)
  3. customdried under vacuum
  4. customto provide the product

Sources & evidence

ORD record
ord-752ab74b2ae9495e8b01c107a13baeed
Source dataset
uspto-grants-2016_01
Patent number
US09227954B2

Reaction notes

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