Hydrochloric Acid → HCID 66589561, compound

HRID 588023Notes

Reaction equation

HRID 588023 reaction equation
[O:1]=[C:2]1[CH:7]([N:8]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:17][NH:18][C:19](=[O:45])[NH:20][C:21]4[CH:22]=[CH:23][C:24]([CH3:44])=[C:25]([CH:43]=4)[O:26][C:27](=[O:42])[CH2:28][N:29]4[CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31][CH2:30]4)[CH:14]=3)[C:9]2=[O:46])[CH2:6][CH2:5][C:4](=[O:47])[NH:3]1.[ClH:48]>C(Cl)Cl.CCOCC>[ClH:48].[N:29]1([CH2:28][C:27]([O:26][C:25]2[CH:43]=[C:21]([NH:20][C:19]([NH:18][CH2:17][C:13]3[CH:14]=[C:15]4[C:10](=[CH:11][CH:12]=3)[C:9](=[O:46])[N:8]([CH:7]3[CH2:6][CH2:5][C:4](=[O:47])[NH:3][C:2]3=[O:1])[CH2:16]4)=[O:45])[CH:22]=[CH:23][C:24]=2[CH3:44])=[O:42])[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66589469HCID 66589469, compound

Product 1

HCID 66589561HCID 66589561, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a mixture of tert-butyl 4-(2-(5-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)ureido)-2-methylphenoxy)-2-oxoethyl)piperazine-1-carboxylate (0.65 g, 1.0 mmol) in methylene chloride (50 mL) is added 2M HCl in ether (1 mL), and the mixture will be stirred for 24 hrs. The solid precipitate is filtered, rinsed with DCM (10 mL), and dried under vacuum to provide the product.

Workup

  1. filtrationThe solid precipitate is filtered
  2. washrinsed with DCM (10 mL)
  3. customdried under vacuum
  4. customto provide the product

Sources & evidence

ORD record
ord-2cf1d11cc7d9471e96805e6a6b46f0b3
Source dataset
uspto-grants-2016_01
Patent number
US09227954B2

Reaction notes

Loading…