(4-Aminophenoxy)benzene → HCID 71496600, compound

HRID 588051Notes

Reaction equation

HRID 588051 reaction equation
Cl[C:2]1[N:23]=[CH:22][CH:21]=[CH:20][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:9][CH:8]=1)=[O:5].ClC1N=CC=CC=1C(NC1C=CC=C(Cl)C=1)=O.[O:41]([C:48]1[CH:54]=[CH:53][C:51]([NH2:52])=[CH:50][CH:49]=1)[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1.NC1CCN(CC2C=CC=CC=2)CC1>>[O:41]([C:48]1[CH:49]=[CH:50][C:51]([NH:52][C:2]2[N:23]=[CH:22][CH:21]=[CH:20][C:3]=2[C:4]([NH:6][C:7]2[CH:12]=[CH:11][C:10]([O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:9][CH:8]=2)=[O:5])=[CH:53][CH:54]=1)[C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1

Participants

5

Reactant 4

HCID 8764(4-Aminophenoxy)benzeneHCID 4158521-Benzyl-4-piperidylamineHCID 1419048HCID 1419048, compoundHCID 4548294HCID 4548294, compound

Product 1

HCID 71496600HCID 71496600, compoundYield 77.8%

Procedure

The title compound was prepared in the same manner as in Example 1, with the exception that 2-chloro-(N-4-phenoxyphenyl)nicotinamide of Preparation Example 6, instead of 2-chloro-(N-3-chlorophenyl)nicotinamide, and 4-phenoxyaniline, instead of 4-amino-1-benzylpiperidine, were used in the same molar amounts (Yield: 77.8%). 1H NMR (DMSO-d6) δ 10.50 (s, 1H), 10.33 (s, 1H), 8.35 (d, 1H), 8.25 (d, 1H), 7.69˜7.82 (m, 4H), 7.30˜7.46 (m, 4H), 6.88˜7.18 (m, 11H) ppm.

Sources & evidence

ORD record
ord-ca9c723f1d634a71b4e5c7b50d7eca7c
Source dataset
uspto-grants-2016_01
Patent number
US09227955B2

Reaction notes

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