HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 588101Generated: October 31, 2026
Hydrochloric Acid → (3S,4R)-1-methyl-4-phenylpyrrolidin-3-amine hydrochloride
https://huagongshe.com/reaction/588101
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl((3S,4R)-1-methyl-4-phenylpyrrolidin-3-yl)carbamate | HCID 118371748 | — |
| Product | (3S,4R)-1-methyl-4-phenylpyrrolidin-3-amine hydrochloride | HCID 118365041 | — |
Reaction Steps
tert-Butyl((3S,4R)-1-methyl-4-phenylpyrrolidin-3-yl)carbamate (521 mg, 1.885 mmol) was dissolved in methanolic HCl, (3 N, 10 mL) and heated to 50° C. for 2 h. The reaction mixture was concentrated in vacuo to afford (3S,4R)-1-methyl-4-phenylpyrrolidin-3-amine hydrochloride, which was carried onto the next step without further purification. MS ESI calc'd. For C11H16N2 [M+1]+ 177. found 177.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09226922B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-77eb3c8703bc40a59c1ccc6273cb97a6 |
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| Source note | uspto-grants-2016_01 |
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