反应详情

温度

50 °C

tert-Butyl((3S,4R)-1-methyl-4-phenylpyrrolidin-3-yl)carbamate (521 mg, 1.885 mmol) was dissolved in methanolic HCl, (3 N, 10 mL) and heated to 50° C. for 2 h. The reaction mixture was concentrated in vacuo to afford (3S,4R)-1-methyl-4-phenylpyrrolidin-3-amine hydrochloride, which was carried onto the next step without further purification. MS ESI calc'd. For C11H16N2 [M+1]+ 177. found 177.

1. concentrationThe reaction mixture was concentrated in vacuo