反应详情

温度

80 °C

(3S,4R)-1-Methyl-4-phenylpyrrolidin-3-amine hydrochloride (556 mg, 2.231 mmol) was dissolved in HCl (2 N, 4 mL) and potassium cyanate (905 mg, 11.16 mmol) was added. The reaction mixture was stirred at 80° C. for 3 h. The reaction was quenched with sat. sodium bicarbonate and extracted with EtOAc followed by 3:1 chloroform/IPA. The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo to give 1-((3S,4R)-1-methyl-4-phenylpyrrolidin-3-yl)urea, which was carried onto the next step without further purification. MS ESI calc'd. For C12H17N3O [M+1]+ 220. found 220.

1. customThe reaction was quenched with sat. sodium bicarbonate
2. extractionextracted with EtOAc
3. dry with materialThe combined organic layers were dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo