Hydrochloric Acid → HCID 118271779, compound

Participants

Reaction Conditions

Reaction Steps

A 5 mL microwave vial was charged with 1-(amino(phenyl)methyl)cyclopentanol (191.3 mg, 1.0 mmol), potassium cyanate (406 mg, 5.00 mmol), water (1 ml) and hydrochloric acid (6N, 0.5 ml, 3.00 mmol). The vial was capped and heated to 80° C. for 1 h in a microwave. The contents of the vial were cooled to room temperature, the formed precipitate filtered, washed through with water and dried in a vacuum oven (40° C.). The crude 1-((1-hydroxycyclopentyl)(phenyl)methyl)urea was taken forward without further purification. MS: [M+H]+ m/z 235.

Provenance & Evidence