Hydrochloric Acid → HCID 118271779, compound

HRID 588154Notes

Reaction equation

HRID 588154 reaction equation
[NH2:1][CH:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1([OH:8])[CH2:7][CH2:6][CH2:5][CH2:4]1.[O-:15][C:16]#[N:17].[K+].Cl>O>[OH:8][C:3]1([CH:2]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:1][C:16]([NH2:17])=[O:15])[CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 349467HCID 349467, compoundHCID 11378442Potassium cyanate

Product 1

HCID 118271779HCID 118271779, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A 5 mL microwave vial was charged with 1-(amino(phenyl)methyl)cyclopentanol (191.3 mg, 1.0 mmol), potassium cyanate (406 mg, 5.00 mmol), water (1 ml) and hydrochloric acid (6N, 0.5 ml, 3.00 mmol). The vial was capped and heated to 80° C. for 1 h in a microwave. The contents of the vial were cooled to room temperature, the formed precipitate filtered, washed through with water and dried in a vacuum oven (40° C.). The crude 1-((1-hydroxycyclopentyl)(phenyl)methyl)urea was taken forward without further purification. MS: [M+H]+ m/z 235.

Workup

  1. customThe vial was capped
  2. temperatureThe contents of the vial were cooled to room temperature
  3. filtrationthe formed precipitate filtered
  4. washwashed through with water
  5. customdried in a vacuum oven (40° C.)
  6. customThe crude 1-((1-hydroxycyclopentyl)(phenyl)methyl)urea was taken forward without further purification

Sources & evidence

ORD record
ord-0e9f0147b218486bba84f8c224f4d0f0
Source dataset
uspto-grants-2016_01
Patent number
US09226922B2

Reaction notes

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