Hydrochloric Acid → HCID 118271815, compound

Participants

Reaction Steps

To (R)-tert-butyl 1-(2-fluoro-6-methoxybenzyl)piperidin-3-ylcarbamate (3.52 g, 10.40 mmol) was added methanolic HCl (3 N, 50 mL) and the reaction mixture was heated to reflux for 3 h. The volatiles were removed in vacuo to afford (R)-1-(2-fluoro-6-methoxybenzyl)-piperidin-3-amine hydrochloride. MS ESI calc'd. For C13H19FN2O [M+1]+ 239. found 239.

Provenance & Evidence