Hydrochloric Acid → HCID 118271815, compound

HRID 588169Notes

Reaction equation

HRID 588169 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][CH2:8][C@@H:7]([NH:11]C(=O)OC(C)(C)C)[CH2:6]1.[ClH:25]>>[ClH:25].[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][CH2:8][C@@H:7]([NH2:11])[CH2:6]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 118365325HCID 118365325, compound

Product 1

HCID 118271815HCID 118271815, compound

Procedure

To (R)-tert-butyl 1-(2-fluoro-6-methoxybenzyl)piperidin-3-ylcarbamate (3.52 g, 10.40 mmol) was added methanolic HCl (3 N, 50 mL) and the reaction mixture was heated to reflux for 3 h. The volatiles were removed in vacuo to afford (R)-1-(2-fluoro-6-methoxybenzyl)-piperidin-3-amine hydrochloride. MS ESI calc'd. For C13H19FN2O [M+1]+ 239. found 239.

Workup

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 3 h
  3. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-c13d0424e572463094bc630377788614
Source dataset
uspto-grants-2016_01
Patent number
US09226922B2

Reaction notes

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