反应详情

A mixture of methyl 2-oxocyclopentanecarboxylate (67 g, 0.47 mol), K2CO3 (163 g, 1.18 mol) and MeI (167 g, 1.18 mol) in acetone (500 mL) was heated under reflux for 12 h. The mixture was cooled to ambient temperature and then concentrated. The residue was dissolved in EtOAc (800 mL) and the resulting solution was washed with saturated aqueous NaHCO3 (500 mL×3) and brine (300 mL×1), dried over anhydrous sodium sulfate, and concentrated to dryness. The residue was purified by distillation to afford methyl 1-methyl-2-oxocyclopentanecarboxylate (60.5 g, 82% yield).

1. temperaturewas heated
2. temperatureunder reflux for 12 h
3. concentrationconcentrated
4. dissolutionThe residue was dissolved in EtOAc (800 mL)
5. washthe resulting solution was washed with saturated aqueous NaHCO3 (500 mL×3) and brine (300 mL×1)
6. dry with materialdried over anhydrous sodium sulfate
7. concentrationconcentrated to dryness
8. distillationThe residue was purified by distillation