反应详情

温度

150 °C

To a solution of 2-oxoindoline-5-carbohydrazide (200 mg, 1.05 mmol) in n-BuOH/DMF (6 ml/2 ml) was added benzonitrile (324 mg, 3.14 mmol) and potassium carbonate (29 mg, 0.21 mmol). The mixture was heated at 150° C. for 3 hours under microwave irradiation. CHCl3/MeOH (20 ml/1 ml) was added to the mixture and insoluble solid was removed by filtration. The filtrate was concentrated. H2O was added to the residue and extracted with CHCl3. The organic layer was dried over Na2SO4 and concentrated in vacuo. Purification by column chromatography (CHCl3/MeOH) gave 5-(3-phenyl-1H-1,2,4-triazol-5-yl)indolin-2-one (15 mg).

1. customwas removed by filtration
2. concentrationThe filtrate was concentrated
3. additionH2O was added to the residue
4. extractionextracted with CHCl3
5. dry with materialThe organic layer was dried over Na2SO4
6. concentrationconcentrated in vacuo
7. customPurification by column chromatography (CHCl3/MeOH)