Water → N-Isopropyl-4'-nitrobiphenyl-4-sulfonamide

HRID 588341Notes

Reaction equation

HRID 588341 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].[N+:5]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)([O-:7])=[O:6].O>CN(C=O)C>[CH:1]([NH:4][S:20]([C:17]1[CH:18]=[CH:19][C:14]([C:11]2[CH:12]=[CH:13][C:8]([N+:5]([O-:7])=[O:6])=[CH:9][CH:10]=2)=[CH:15][CH:16]=1)(=[O:21])=[O:22])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 6363IsopropylamineHCID 27601854'-Nitrobiphenyl-4-sulfonyl chloride

Product 1

HCID 59694089N-Isopropyl-4'-nitrobiphenyl-4-sulfonamide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.22 ml (2.52 mmol) of isopropylamine is added to a solution of 150 mg (0.50 mmol) of 4′-nitrobiphenyl-4-sulfonyl chloride in 2.0 ml of DMF. After 18 h at room temperature, 2.5 ml of water are added to the reaction mixture. The resulting precipitate is filtered off with suction and dried under high vacuum. 126 mg (64.4% of theory) of the title compound are obtained and reacted further without further purification.

Workup

  1. filtrationThe resulting precipitate is filtered off with suction
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-8623e3801f884934835b0b8a3234583a
Source dataset
uspto-grants-2016_01
Patent number
US09227964B2

Reaction notes

Loading…