HRID588392

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID117652878

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC[C@@H](Nc2ncccc2Cl)C1

HCID117652951

1-Piperidinecarboxylic acid, 3-[(3-chloro-2-pyridinyl)amino]-, 1,1-dimethylethyl ester, (3R)-

C15H22ClN3O2

PRODUCTS

生成物

结构：Cc1cnc2c(c1)nnn2-c1ccc(C(=O)N(c2ncccc2Cl)[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)nc1

HCID118898566

未命名化合物

收率 43.2%

PROCEDURE

实验过程

Prepared according to General Procedure A and C starting from Preparation 1 tert-butyl (3R)-3-[(3-chloropyridin-2-yl)amino]piperidine-1-carboxylate (3.22 g, 10.3 mmol) and Preparation 8 5-(6-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)pyridine-2-carboxylic acid (2.51 g, 9.83 mmol) to provide 2.33 g (43%) of the product as a solid.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-751ca63fc8614dde97b66a62116e2873
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09227956B2
来源说明: uspto-grants-2016_01

反应 SMILES

[Cl:1][C:2]1[C:3]([NH:8][C@@H:9]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[CH3:22][C:23]1[CH:24]=[C:25]2[N:31]=[N:30][N:29]([C:32]3[CH:33]=[CH:34][C:35]([C:38](O)=[O:39])=[N:36][CH:37]=3)[C:26]2=[N:27][CH:28]=1>>[Cl:1][C:2]1[C:3]([N:8]([C:38]([C:35]2[CH:34]=[CH:33][C:32]([N:29]3[C:26]4=[N:27][CH:28]=[C:23]([CH3:22])[CH:24]=[C:25]4[N:31]=[N:30]3)=[CH:37][N:36]=2)=[O:39])[C@@H:9]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]2)=[N:4][CH:5]=[CH:6][CH:7]=1