Pyrrolidine → 1-Methyl-N-(2-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(pyrrolidine-1-carbonyl)-1H-pyrazole-5-carboxamide

HRID 588427Notes

Reaction equation

HRID 588427 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:6][N:7]1[C:11]([C:12](=[O:29])[NH:13][C:14]2[CH:15]=[CH:16][C:17]3[N:18]([N:20]=[C:21]([C:23]4[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=4)[N:22]=3)[CH:19]=2)=[C:10]([C:30](O)=[O:31])[CH:9]=[N:8]1>>[CH3:6][N:7]1[C:11]([C:12]([NH:13][C:14]2[CH:15]=[CH:16][C:17]3[N:18]([N:20]=[C:21]([C:23]4[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=4)[N:22]=3)[CH:19]=2)=[O:29])=[C:10]([C:30]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:31])[CH:9]=[N:8]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 894645241-Methyl-5-(2-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 715381441-Methyl-N-(2-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(pyrrolidine-1-carbonyl)-1H-pyrazole-5-carboxamide

Procedure

Using pyrrolidine and 1-methyl-5-(2-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. White solid (53 mg, 33%). Mp.: 251° C. MS: m/z=417.3 (M+H+).

Sources & evidence

ORD record
ord-1a3ebc05132542bab8d6a29bc8700151
Source dataset
uspto-grants-2016_01
Patent number
US09227970B2

Reaction notes

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