HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Benzyl 2-(1-aminoethyl)thiazole-5-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzyl 2-(1-(tert-butoxycarbonylamino)ethyl)thiazole-5-carboxylate | HCID 67395421 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Benzyl 2-(1-aminoethyl)thiazole-5-carboxylate hydrochloride | HCID 67394933 | 100% |
Reaction Steps
To a solution of benzyl 2-(1-(tert-butoxycarbonylamino)ethyl)thiazole-5-carboxylate (0.55 g, 0.55 mmol) in THF (2 mL) was added 4M HCl in dioxane (0.5 ml). The reaction solution was stirred at room temperature overnight. The solution was concentrated to dryness to afford a colorless oil (0.45 g, 100%). LC-MS: (FA) ES+ 263.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227951B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-ca0ae3fa22344cdf846acc52859dd646 |
| Source note | uspto-grants-2016_01 |