Hydrochloric Acid → Benzyl 2-(1-aminoethyl)thiazole-5-carboxylate hydrochloride

HRID 588504Notes

Reaction equation

HRID 588504 reaction equation
C(OC([NH:8][CH:9]([C:11]1[S:12][C:13]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[CH:14][N:15]=1)[CH3:10])=O)(C)(C)C.[ClH:26]>C1COCC1.O1CCOCC1>[ClH:26].[NH2:8][CH:9]([C:11]1[S:12][C:13]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[CH:14][N:15]=1)[CH3:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67395421Benzyl 2-(1-(tert-butoxycarbonylamino)ethyl)thiazole-5-carboxylate

Product 1

HCID 67394933Benzyl 2-(1-aminoethyl)thiazole-5-carboxylate hydrochlorideYield 100%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of benzyl 2-(1-(tert-butoxycarbonylamino)ethyl)thiazole-5-carboxylate (0.55 g, 0.55 mmol) in THF (2 mL) was added 4M HCl in dioxane (0.5 ml). The reaction solution was stirred at room temperature overnight. The solution was concentrated to dryness to afford a colorless oil (0.45 g, 100%). LC-MS: (FA) ES+ 263.

Workup

  1. concentrationThe solution was concentrated to dryness

Sources & evidence

ORD record
ord-ca0ae3fa22344cdf846acc52859dd646
Source dataset
uspto-grants-2016_01
Patent number
US09227951B2

Reaction notes

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