Hydrochloric Acid → HCID 67306731, compound

HRID 588533Notes

Reaction equation

HRID 588533 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([NH:23][C:24]([N:26]3[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]3)=[O:25])=[CH:21][N:22]=2)[N:19]=1.[ClH:39]>C(Cl)Cl>[ClH:39].[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([NH:23][C:24]([N:26]3[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]3)=[O:25])=[CH:21][N:22]=2)[N:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 45274022HCID 45274022, compound

Product 1

HCID 67306731HCID 67306731, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(R)-tert-butyl 4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-ylcarbamoyl)piperazine-1-carboxylate (Example 15; 10 mg, 0.019 mmol) was dissolved in 0.2 mL DCM, followed by addition of 0.5 mL 4 N HCl (dioxane) solution in one portion. After stirring at ambient temperature overnight, the reaction was concentrated to yield the final product salt form as a light yellowish solid. MS (apci) m/z=428.2 (M+H).

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-afc8a8ab9b274d05add75fdc586d6fc4
Source dataset
uspto-grants-2016_01
Patent number
US09227975B2

Reaction notes

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