Hydrochloric Acid → HCID 45274026, compound

HRID 588535Notes

Reaction equation

HRID 588535 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([NH:23][C:24]([N:26]3[CH2:32][CH:31]4[N:33](C(OC(C)(C)C)=O)[CH:28]([CH2:29][CH2:30]4)[CH2:27]3)=[O:25])=[CH:21][N:22]=2)[N:19]=1.[ClH:41]>C(Cl)Cl>[ClH:41].[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([NH:23][C:24]([N:26]3[CH2:27][CH:28]4[NH:33][CH:31]([CH2:30][CH2:29]4)[CH2:32]3)=[O:25])=[CH:21][N:22]=2)[N:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58334490HCID 58334490, compound

Product 1

HCID 45274026HCID 45274026, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 3-(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-ylcarbamoyl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate (Example 23, 10 mg, 0.018 mmol) was dissolved in 0.1 mL DCM, followed by addition of 0.5 mL 4 N HCl (dioxane) solution in one portion. After stirring at ambient temperature overnight, the reaction was concentrated to yield the final product salt form as a light yellowish solid. MS (apci) m/z=454.1 (M+H).

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-642bcb92f74842709b9eca3a58c006eb
Source dataset
uspto-grants-2016_01
Patent number
US09227975B2

Reaction notes

Loading…