N-Iodosuccinimide → CID 86717264

HRID 588562Notes

Reaction equation

HRID 588562 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[CH:16][C:3]=12.[I:17]N1C(=O)CCC1=O>C(#N)C>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[C:16]([I:17])[C:3]=12

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 867172634-chloro-5-phenyl-1H-pyrazolo[3,4-c]pyridazine

Product 1

HCID 86717264CID 86717264

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A suspension of 4-chloro-5-phenyl-1H-pyrazolo[3,4-c]pyridazine (2.44 g, 10.6 mmol) and N-iodosuccinimide (3.58 g, 15.9 mmol) in acetonitrile (106 mL) was heated at reflux for 1 d. The yellow solid was collected by filtration whilst warm to provide a mixture of the title compound and starting material (9:1, 4 g).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1 d
  3. filtrationThe yellow solid was collected by filtration
  4. temperaturewhilst warm
  5. customto provide

Sources & evidence

ORD record
ord-6315fa9e8ee64983b46b55d62701630f
Source dataset
uspto-grants-2016_01
Patent number
US09227976B2

Reaction notes

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