2,2,2-Trifluoroethanol → HCID 86717304, compound

HRID 588607Notes

Reaction equation

HRID 588607 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:3]=12.[F:23][C:24]([F:28])([F:27])[CH2:25]O>>[Cl:1][C:2]1[C:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[N:6][N:5]=[C:4]2[N:14]([CH2:25][C:24]([F:28])([F:27])[F:23])[N:15]=[C:16]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:3]=12

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 86697018CID 86697018

Product 1

HCID 86717304HCID 86717304, compound

Procedure

Compound IIk was synthesized from 4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine and 2,2,2-trifluoroethanol following the general procedure for the Mitsunobu reaction as described above.

Workup

  1. customfor the Mitsunobu reaction

Sources & evidence

ORD record
ord-74116dd3b7f343f1a0b24d8a0c5dffa5
Source dataset
uspto-grants-2016_01
Patent number
US09227976B2

Reaction notes

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