反应详情

温度

60 °C

A suspension of N-[3-(3-fluorophenyl)-1H-pyrazol-5-yl]acetamide (7.6 g, 34.7 mmol), iodic acid (1.5 g, 8.5 mmol) and iodine (4.4 g, 17.3 mmol) in ethanol (200 mL) was heated at 60° C. for 1 h and cooled to room temperature. The reaction mixture was concentrated in vacuo and partitioned between CH2Cl2 and 2 M Na2S2O3 aq. solution. The layers were separated and the organic washed with brine, dried (MgSO4), and concentrated in vacuo to provide the title compound as a solid (10.8 g).

1. temperaturecooled to room temperature
2. concentrationThe reaction mixture was concentrated in vacuo
3. custompartitioned between CH2Cl2 and 2 M Na2S2O3 aq. solution
4. customThe layers were separated
5. washthe organic washed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated in vacuo