反应详情

1-Adamantanethiol (278 mg) was dissolved in dimethyl sulfoxide (10 mL). Sodium hydride (60% in mineral oil, 42 mg) was added, and the solution was stirred at room temperature for 20 minutes. 2-Bromo-6-fluorobenzonitrile (300 mg) was added and the solution was heated to 130° C. for 1 hour. The solution was cooled, added to diethyl ether, washed with 1 M aqueous HCl three times, washed with brine, and dried over anhydrous sodium sulfate. After filtration, the solvent was removed under vacuum to yield the title compound.

1. temperaturethe solution was heated to 130° C. for 1 hour
2. temperatureThe solution was cooled
3. washwashed with 1 M aqueous HCl three times
4. washwashed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationAfter filtration
7. customthe solvent was removed under vacuum