Hydrochloric Acid → 2-(5-(2-Chloropheny)-4-chloro-2-methoxyphenylamino)-1-(piperazin-1-yl)ethanone

HRID 588779Notes

Reaction equation

HRID 588779 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:33])[CH2:15][NH:16][C:17]2[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:29])[C:20]([Cl:30])=[CH:19][C:18]=2[O:31][CH3:32])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.CO>C(Cl)Cl>[Cl:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[C:21]1[C:20]([Cl:30])=[CH:19][C:18]([O:31][CH3:32])=[C:17]([NH:16][CH2:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:33])[CH:22]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 90462596tert-Butyl-4-(2-(5-(2-Chloropheny)-4-chloro-2-methoxyphenylamino)acetyl)piperazine-1-carboxylate

Product 1

HCID 1176104652-(5-(2-Chloropheny)-4-chloro-2-methoxyphenylamino)-1-(piperazin-1-yl)ethanone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl-4-(2-(5-(2-chlorophenyl)-4-chloro-2-methoxyphenylamino)acetyl)piperazine-1-carboxylate (150 mg, 0.304 mmol) in DCM (2 mL), a solution of HCl in MeOH (10 mL, 29 mmol) was added. The mixture was stirred at room temperature for 1 h and then concentrated in vacuo to afford the crude product which was used in the next step without further purification.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ce56f2a4ea9b49868b3e0877fa7072cf
Source dataset
uspto-grants-2016_01
Patent number
US09227978B2

Reaction notes

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