反应详情

The mixture of 4-((4,5-dichloro-2-methoxybenzyl)carbamoyl)piperidine-1-carboxylate (987 mg, 2.37 mmol) in HCl/MeOH (20 mL, 57.2 mmol) was stirred at room temperature for 1 h. Then the solvent was evaporated in vacuo and the residue was dissolved with dichloromethane (5 mL). To this mixture, NaH (85 mg, 3.55 mmol) was added. Then the resulting mixture was stirred at room temperature for 30 min. The solvent was removed under reduced pressure to yield the crude product (800 mg).

1. customThen the solvent was evaporated in vacuo
2. dissolutionthe residue was dissolved with dichloromethane (5 mL)
3. stirringThen the resulting mixture was stirred at room temperature for 30 min
4. customThe solvent was removed under reduced pressure