Triethylamine → HCID 90462565, compound

HRID 588853Notes

Reaction equation

HRID 588853 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([N:11]2[CH2:18][CH:17]3[CH:13]([CH2:14][NH:15][CH2:16]3)[CH2:12]2)=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].CCN([CH2:24][CH3:25])CC.[S:26](Cl)(Cl)(=[O:28])=[O:27]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([N:11]2[CH2:12][CH:13]3[CH:17]([CH2:16][N:15]([S:26]([CH:24]=[CH2:25])(=[O:28])=[O:27])[CH2:14]3)[CH2:18]2)=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 24648Sulfuryl chlorideHCID 66211026HCID 66211026, compound

Product 1

HCID 90462565HCID 90462565, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (3,4-dichlorophenyl)(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone (100 mg, 0.35 mmol) in DCM (10 mL) at 0° C., Et3N (106 mg, 1 mmol) was added followed by sulfonyl chloride (60 mg, 0.37 mmol). The resulting mixture was stirred at room temperature overnight. The mixture was partitioned between DCM and water. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by Isolera One (silica gel cartridge, 10-100% ethyl acetate/hexanes) to afford the desired product (14 mg, 11%). 1H NMR (300 MHz, CDCl3) δ: 7.60 (d, J=2.0 Hz, 1H), 7.51 (d, J=8.2 Hz, 1H), 7.35 (dd, J=2.0, 8.2 Hz, 1H), 6.50 (dd, J=9.9, 16.5 Hz, 1H), 6.30 (d, J=16.6 Hz, 1H), 6.09 (d, J=9.9 Hz, 1H), 2.90-4.10 (m, 10H). ESI-MS m/z: 375.0[M+H]+.

Workup

  1. customThe mixture was partitioned between DCM and water
  2. dry with materialThe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe residue was purified by Isolera One (silica gel cartridge, 10-100% ethyl acetate/hexanes)

Sources & evidence

ORD record
ord-cbe8797e18f648c8856604afa3116b95
Source dataset
uspto-grants-2016_01
Patent number
US09227978B2

Reaction notes

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