Hydrochloric Acid → HCID 59668912, compound

HRID 588955Notes

Reaction equation

HRID 588955 reaction equation
[CH3:1][CH:2]([CH3:21])[C@H:3]([NH:11][C:12]([O:14][CH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:13])[C:4]([O:6]C(C)(C)C)=[O:5].Cl.O1CCOCC1>>[CH3:1][CH:2]([CH3:21])[C@H:3]([NH:11][C:12]([O:14][CH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:13])[C:4]([OH:6])=[O:5]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59668895HCID 59668895, compound

Product 1

HCID 59668912HCID 59668912, compoundYield 100%

Procedure

To a Compound 46 (S)-tert-butyl 3-methyl-2-((tetrahydro-2H-pyran-4-yloxy)carbonylamino)butanoate (0.21 g, 0.697 mmol) was added HCl in dioxane (15 mL, 60.0 mmol) and the mixture was stirred at room temperature under nitrogen for three hours. The reaction was done and concentrated under reduced pressure to provide F47 (S)-3-methyl-2-((tetrahydro-2H-pyran-4-yloxy)carbonylamino)butanoic acid (0.1694 g, 0.691 mmol, 100% yield) as a clear wax.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-de1190deead54ce8838dd3db49712714
Source dataset
uspto-grants-2016_01
Patent number
US09227961B2

Reaction notes

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