Trifluoroacetic acid → HCID 117607712, compound

HRID 58903Notes

Reaction equation

HRID 58903 reaction equation
[C:1]1([CH2:6][C@H:7]([NH:14][C:15](=[O:34])[C@@H:16]([NH:26]C(=O)OC(C)(C)C)[CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[C:8]([C@@:10]2([CH3:13])[CH2:12][O:11]2)=[O:9])[CH2:5][CH2:4][CH2:3][CH:2]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:26][C@@H:16]([CH2:17][C:18]1[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=1)[C:15]([NH:14][C@@H:7]([CH2:6][C:1]1[CH2:5][CH2:4][CH2:3][CH:2]=1)[C:8]([C@@:10]1([CH3:13])[CH2:12][O:11]1)=[O:9])=[O:34]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131737024HCID 131737024, compound

Product 1

HCID 117607712HCID 117607712, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl ((S)-1-(((S)-3-(cyclopent-1-en-1-yl)-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)amino)-3-(4-methoxyphenyl)-1-oxopropan-2-yl)carbamate (0.99 g, 2.1 mmol) was added DCM (5 mL) and TFA (5 mL). The mixture was allowed to stand at ambient temperature for 30 min then it was concentrated to provide crude (S)-2-amino-N-((S)-3-(cyclopent-1-en-1-yl)-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-(4-methoxyphenyl)propanamide (quant.) and carried forward without further purification.

Workup

  1. concentrationit was concentrated

Sources & evidence

ORD record
ord-62cb53faf4ae462594c99baa602314e2
Source dataset
uspto-grants-2016_09
Patent number
US09434761B2

Reaction notes

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