Hydrochloric Acid → HCID 131734456, compound

HRID 589126Notes

Reaction equation

HRID 589126 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[C:16]3[O:15][CH2:14][C@H:13]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)[N:12]4[C:23]([N:25]5[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]5)=[N:24][C:10]([C:11]=34)=[CH:9][CH:8]=2)=[C:5]([CH3:38])[O:4][N:3]=1.CO.[ClH:41]>>[ClH:41].[ClH:41].[ClH:41].[CH3:1][C:2]1[C:6]([C:7]2[C:16]3[O:15][CH2:14][C@H:13]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)[N:12]4[C:23]([N:25]5[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]5)=[N:24][C:10]([C:11]=34)=[CH:9][CH:8]=2)=[C:5]([CH3:38])[O:4][N:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 90438028HCID 90438028, compound

Product 1

HCID 131734456HCID 131734456, compoundYield 92%

Procedure

tert-Butyl 4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperazine-1-carboxylate (45 mg, 0.087 mmol) was stirred in 4 N HCl in dioxanes (3 mL) and methanol (2 mL) for 30 min, at which time the solvent was evaporated to give the title compound (45 mg, 92%). LCMS calc. for C27H32N7O3 (M+H)+: m/z=417.2. found: 417.3.

Workup

  1. customat which time the solvent was evaporated

Sources & evidence

ORD record
ord-bcb1127eca5544398be803388451cab6
Source dataset
uspto-grants-2016_01
Patent number
US09227985B2

Reaction notes

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