Nitric Acid → HCID 90410240, compound

HRID 589131Notes

Reaction equation

HRID 589131 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[OH:12].O.[N+:14]([O-])([OH:16])=[O:15]>C(Cl)Cl>[Br:1][C:2]1[C:3]([OH:12])=[C:4]([N+:14]([O-:16])=[O:15])[C:5]([N+:9]([O-:11])=[O:10])=[C:6]([F:8])[CH:7]=1

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 962WaterHCID 132681792-Bromo-4-fluoro-5-nitrophenol

Product 1

HCID 90410240HCID 90410240, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 2-bromo-4-fluoro-5-nitrophenol (4.0 g, 17 mmol) in methylene chloride (29.5 mL), 2.0 M nitric acid in DCM (25 mL) was added and the mixture was stirred for 15 min at room temperature. The mixture was poured over cold water and extracted with methylene chloride to give the product.

Workup

  1. extractionextracted with methylene chloride
  2. customto give the product

Sources & evidence

ORD record
ord-7fcf471009b9404c90fdba0c7e9bf2ee
Source dataset
uspto-grants-2016_01
Patent number
US09227985B2

Reaction notes

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