Hydrochloric Acid → HCID 67294471, compound

HRID 589161Notes

Reaction equation

HRID 589161 reaction equation
C[Si](C)(C)CCOC[N:7](COCC[Si](C)(C)C)[C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17]3[CH:18]=[N:19][C:20]([C:23]4[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([CH2:31][OH:32])[CH:24]=4)=[CH:21][CH:22]=3)=[C:12]2[N:11]=[C:10]([CH:33]2[CH2:39][CH:38]3[N:40]([C:41](OC(C)(C)C)=[O:42])[CH:35]([CH2:36][CH2:37]3)[CH2:34]2)[C:9]=1[Br:48].Cl.[O:60]1CCOC[CH2:61]1>O>[NH2:7][C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17]3[CH:18]=[N:19][C:20]([C:23]4[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([CH2:31][OH:32])[CH:24]=4)=[CH:21][CH:22]=3)=[C:12]2[N:11]=[C:10]([CH:33]2[CH2:34][CH:35]3[N:40]([C:41](=[O:42])[CH2:61][OH:60])[CH:38]([CH2:37][CH2:36]3)[CH2:39]2)[C:9]=1[Br:48]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67294465HCID 67294465, compound

Product 1

HCID 67294471HCID 67294471, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-(3-(hydroxymethyl)-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate (219 mg) was treated with 4N HCl in dioxane (4 mL) and water (1 mL) and the resulting mixture was stirred for 40 minutes, concentrated and lyophilized to provide the title compound.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-46855214bab94be488ef1b12a6b00928
Source dataset
uspto-grants-2016_01
Patent number
US09227971B2

Reaction notes

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