Hydrochloric Acid → Hydrochloric Acid

HRID 589163Notes

Reaction equation

HRID 589163 reaction equation
[NH2:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:12]=[N:13][C:14]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:15][CH:16]=3)=[C:6]2[N:5]=[C:4](C2CC3N(C(OC(C)(C)C)=O)C(CC3)C2)[C:3]=1[S:38]([CH3:41])(=[O:40])=[O:39].[ClH:42].O1[CH2:48][CH2:47]OCC1>CO>[CH:48]12[NH:13][CH:14]([CH2:17][CH2:47]1)[CH2:15][CH:16]([C:9]1[C:10]([C:11]3[CH:12]=[N:13][C:14]([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)=[CH:15][CH:16]=3)=[C:6]3[N:5]=[CH:4][C:3]([S:38]([CH3:41])(=[O:40])=[O:39])=[C:2]([NH2:1])[N:7]3[N:8]=1)[CH2:11]2.[ClH:42]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67294907HCID 67294907, compound

Product 2

HCID 313Hydrochloric AcidHCID 131734458HCID 131734458, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the crude tert-butyl 3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate in MeOH (5 mL) was added 4M HCl in 1,4-dioxane at r.t. It was stirred further at room temperature for 2 h, at which time LC/MS analysis confirmed full consumption of the starting material. The solvent was removed in vacuo to afford the desired product as an HCl salt.

Workup

  1. customconsumption of the starting material
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-173ca5aa252f4d71b95f52262715289c
Source dataset
uspto-grants-2016_01
Patent number
US09227971B2

Reaction notes

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