Lithium Hydroxide → HCID 178474497, compound

HRID 589165Notes

Reaction equation

HRID 589165 reaction equation
[C:1]([NH:4][C:5]1[NH:6][C:7]([C:10]([O:12]C)=[O:11])=[N:8][N:9]=1)(=[O:3])[CH3:2].[Li+].[OH-]>C1COCC1.CO.O>[C:1]([NH:4][C:5]1[NH:6][C:7]([C:10]([OH:12])=[O:11])=[N:8][N:9]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 178499167HCID 178499167, compound

Product 1

HCID 178474497HCID 178474497, compoundYield 89.3%

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of methyl 5-acetamido-4H-1,2,4-triazole-3-carboxylate (500 mg, 2.72 mmol) and LiOH (2.1 eq) in THF/MeOH/H2O (8/4/2 mL) was stirred at 50° C. for 1 h (precipitates formed). All the volatiles were removed and the white solid residue was acidified with 7 mL of HCl (1 N), filtered and washed with H2O to afford the titled compound as a white solid (413 mg), which was used without further purification.

Workup

  1. custom(precipitates formed)
  2. customAll the volatiles were removed
  3. filtrationfiltered
  4. washwashed with H2O

Sources & evidence

ORD record
ord-15c12e69291a4b2b9a522b0c33ace85c
Source dataset
uspto-grants-2016_01
Patent number
US09227971B2

Reaction notes

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