反应详情

温度

50 °C

A mixture of methyl 5-acetamido-4H-1,2,4-triazole-3-carboxylate (500 mg, 2.72 mmol) and LiOH (2.1 eq) in THF/MeOH/H2O (8/4/2 mL) was stirred at 50° C. for 1 h (precipitates formed). All the volatiles were removed and the white solid residue was acidified with 7 mL of HCl (1 N), filtered and washed with H2O to afford the titled compound as a white solid (413 mg), which was used without further purification.

1. custom(precipitates formed)
2. customAll the volatiles were removed
3. filtrationfiltered
4. washwashed with H2O